Table 2.

Metabolic changes in MO-OH-Nap treated 143B cells.

Metabolite	Fold Change (log2)	FDR
6-Phosphogluconic acid	2.93	0.009
Adenine †	−2.66	0.014
Adenosine †	−3.04	0.028
Adenosine 3’,5’-cyclic monophosphate †	−1.73	0.014
Adenosine diphosphate †	−1.72	0.015
Adenosine monophosphate †	−1.20	0.043
Adenosine triphosphate †	−1.81	0.042
Adenylsuccinic acid †	−5.65	0.009
Argininosuccinic acid	−2.91	0.015
Aspartic acid	−2.26	0.009
Citicoline	−4.12	0.009
Creatine	−1.49	0.015
Cystathionine	−2.91	0.009
Cytidine diphosphate ‡	0.59	0.022
Cytidine monophosphate ‡	−1.01	0.047
Cytidine triphosphate ‡	−1.82	0.027
Fructose 1,6-bisphosphate	−1.27	0.044
Fructose 6-phosphate	−1.37	0.011
Fumaric acid	−4.06	0.009
Glucose 1-phosphate	−1.28	0.016
Glutamic acid	−1.68	0.009
Glutamine † ‡	−1.47	0.029
Glutathione	−3.14	0.012
Glycerol 3-phosphate	2.28	0.006
Guanine †	−2.50	0.009
Guanosine †	−3.96	0.009
Guanosine monophosphate †	−2.75	0.016
Hypoxanthine †	1.71	0.030
Inosine †	−1.91	0.028
Lactic acid	−3.02	0.011
Lysine	−1.35	0.043
Malic acid	−3.50	0.009
methylsuccinic acid	−1.42	0.016
NAD	−2.67	0.009
NADP	−2.57	0.009
Nicotinamide ribotide	−2.56	0.009
Ornitine	−1.90	0.016
Oxidized glutathione	−3.26	0.011
Pantothenic acid	−1.90	0.021
Proline	−2.33	0.009
Pyruvic acid	−4.12	0.005
Ribose 5-phosphate †	1.86	0.009
Ribulose 5-phosphate	2.10	0.009
S-Adenosylhomocysteine	−2.96	0.009
Sedoheptulose 7-phosphate	3.62	0.014
Succinic acid	−2.12	0.010
Thymidine ‡	−1.89	0.016
Thymidine monophosphate ‡	2.40	0.009
Thymidine triphosphate ‡	−3.33	0.005
Uracil ‡	−3.51	0.009
Uridine ‡	−3.92	0.009
Uridine diphosphate ‡	−1.39	0.009
Uridine triphosphate ‡	−4.58	0.016
Xanthosine †	−3.62	0.009

Cells were incubated in the presence or absence of 10 μM MO-OH-Nap for 48 hours. Fold change (log 2) and FDR are shown (two tailed t-test). Metabolites denoted with a

^†represent those belonging to the purine metabolism pathway, while those denoted with a

^‡represent metabolites belonging to the pyrimidine pathway.