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. Author manuscript; available in PMC: 2025 Feb 15.
Published in final edited form as: Cancer. 2023 Oct 27;130(4):576–587. doi: 10.1002/cncr.35071

Table 2:

Multivariable Logistic Regression Models for Germline Pathogenic Variant by Self-Reported and Genetic Ancestry

Self-reported Ancestry
OR of gPV 95% CI p
Age at Diagnosis (continuous) 0.98 0.96, 0.99 0.007
Molecular Subtype 0.002
CN-L 1.00
POLE 0.90 0.43, 1.73
MSI-H 1.99 1.37, 2.92
CN-H 1.40 0.93, 2.11
Ancestry, Self-reported 0.015
NH-White 1.00
Black/AA 0.44 0.22, 0.81
Asian 0.76 0.40, 1.35
Hispanic 0.85 0.46, 1.47
AJ 1.49 0.98, 2.23
Genetic Ancestry
OR of gPV 95% CI p
Age at Diagnosis (continuous) 0.97 0.96, 0.99 0.001
Molecular Subtype 0.001
CN-L 1.00
POLE 1.01 0.49, 1.92
MSI-H 2.09 1.43, 3.07
CN-H 1.40 0.92, 2.13
Ancestry, Genetic 0.001
EUR 1.00
AFR 0.42 0.18, 0.85
ASJ 1.62 1.11, 2.34
EAS 0.67 0.29, 1.38
NAM 4.62 0.60, 28.6
SAS 1.45 0.56, 3.28
Mixed 0.61 0.34, 1.03

OR, odds ratio; gPV, germline pathogenic variant; CI, confidence interval; CN-L, copy number-low; POLE, polymerase epsilon ultramutated; MSI-H, microsatellite instability-high; CN-H, copy number-high; NH, non-Hispanic; AA, African American; AJ, self-reported Ashkenazi Jewish; AFR, African; EUR, European; EAS, East Asian; NAM, Native American; SAS, South Asian; ASJ, genetic Ashkenazi Jewish