Table 2:
Multivariable Logistic Regression Models for Germline Pathogenic Variant by Self-Reported and Genetic Ancestry
| Self-reported Ancestry | |||
|---|---|---|---|
| OR of gPV | 95% CI | p | |
| Age at Diagnosis (continuous) | 0.98 | 0.96, 0.99 | 0.007 |
| Molecular Subtype | 0.002 | ||
| CN-L | 1.00 | — | |
| POLE | 0.90 | 0.43, 1.73 | |
| MSI-H | 1.99 | 1.37, 2.92 | |
| CN-H | 1.40 | 0.93, 2.11 | |
| Ancestry, Self-reported | 0.015 | ||
| NH-White | 1.00 | — | |
| Black/AA | 0.44 | 0.22, 0.81 | |
| Asian | 0.76 | 0.40, 1.35 | |
| Hispanic | 0.85 | 0.46, 1.47 | |
| AJ | 1.49 | 0.98, 2.23 | |
| Genetic Ancestry | |||
| OR of gPV | 95% CI | p | |
| Age at Diagnosis (continuous) | 0.97 | 0.96, 0.99 | 0.001 |
| Molecular Subtype | 0.001 | ||
| CN-L | 1.00 | — | |
| POLE | 1.01 | 0.49, 1.92 | |
| MSI-H | 2.09 | 1.43, 3.07 | |
| CN-H | 1.40 | 0.92, 2.13 | |
| Ancestry, Genetic | 0.001 | ||
| EUR | 1.00 | — | |
| AFR | 0.42 | 0.18, 0.85 | |
| ASJ | 1.62 | 1.11, 2.34 | |
| EAS | 0.67 | 0.29, 1.38 | |
| NAM | 4.62 | 0.60, 28.6 | |
| SAS | 1.45 | 0.56, 3.28 | |
| Mixed | 0.61 | 0.34, 1.03 | |
OR, odds ratio; gPV, germline pathogenic variant; CI, confidence interval; CN-L, copy number-low; POLE, polymerase epsilon ultramutated; MSI-H, microsatellite instability-high; CN-H, copy number-high; NH, non-Hispanic; AA, African American; AJ, self-reported Ashkenazi Jewish; AFR, African; EUR, European; EAS, East Asian; NAM, Native American; SAS, South Asian; ASJ, genetic Ashkenazi Jewish