Table 2.
Comparing demographic and clinical characteristics across fatigue subtypes.
| High General/High Exertional Fatigue |
High General/Low Exertional Fatigue |
Moderate General/ Moderate Exertional Fatigue |
Low/No Fatigue |
|
|---|---|---|---|---|
| Estimated sample size | n=175 | n=275 | n=218 | n=397 |
| Age | 1.01 (0.96, 1.00) | 1.05 (1.01, 1.10) | 1.02 (0.97, 1.00) | REF |
| Sex | 5.81 (3.20, 10.53) | 2.00 (1.27, 3.17) | 0.88 (0.48, 1.61) | |
| Race | 3.36 (2.07, 5.47) | 0.79 (0.47, 1.32) | 0.41 (0.17, 1.00) | |
| Education: | ||||
| Less than High School | 5.49 (3.31, 9.12) | 1.76 (0.97, 3.16) | 1.22 (0.53, 2.83) | |
| High School/Vocational | 0.79 (0.49, 1.28) | 1.08 (0.68, 1.72) | 1.38 (0.79, 2.40) | |
| College | 0.40 (0.21, 0.76) | 0.85 (0.52, 1.39) | 0.68 (0.36, 1.28) | |
| Graduate/Professional | 0.06 (0.002, 1.61) | 0.46 (0.22, 0.97) | 0.76 (0.37, 1.58) | |
| Area Deprivation Index (OR for one SD increase in ADI) | 2.03 (1.58, 2.62) | 1.04 (0.83, 1.32) | 0.78 (0.58, 1.06) | |
| Smoking Status: | ||||
| Current Smoker | 0.96 (0.32, 2.88) | 0.28 (0.03, 2.42) | 6.84 (0.73, 64.1) | |
| Former Smoker | 0.60 (0.30, 1.22) | 0.76 (0.37, 1.55) | 3.95 (0.49, 32.0) | |
| Never Smoker | 1.09 (0.54, 2.22) | 0.90 (0.42, 1.92) | 2.67 (0.31, 23.2) | |
| Systolic blood pressure | 1.01 (0.99, 1.02) | 1.01 (1.00, 1.02) | 0.99 (0.98, 1.01) | |
| Body Mass Index (OR for each 1 unit increase in BMI) | 1.20 (1.13, 1.27) | 1.00 (0.95, 1.09) | 1.09 (1.02, 1.16) | |
| Comorbidities: | ||||
| Diabetes | 4.40 (2.61, 7.41) | 1.20 (0.74, 1.94) | 1.61 (0.92, 2.84) | |
| Atrial fibrillation | 1.48 (0.82, 2.47) | 0.97 (0.52, 1.80) | 1.93 (1.04, 3.60) | |
| Coronary heart disease | 0.82 (0.51, 1.30) | 0.80 (0.50, 1.28) | 1.96 (1.10, 3.51) | |
| Medications: | ||||
| Beta Blockers | 0.97 (0.61, 1.54) | 0.86 (0.54, 1.36) | 3.23 (1.41, 7.39) | |
| Loop Diuretics | 2.85 (1.77, 4.58) | 1.00 (0.57, 1.78) | 1.84 (1.02, 3.34) | |
| CNS Depressants | 2.75 (1.55, 4.88) | 1.56 (0.78, 3.10) | 0.88 (0.30, 2.64) | |
| Kidney function(sCr & cystatin C eGFR, ml/min/1.73m2) | 0.98 (0.97, 1.00) | 0.99 (0.98, 1.00) | 0.98 (0.97, 1.00) | |
| Cardiac Biomarkers | ||||
| NT-proBNP (>= 450 pg/mL) | 1.24 (0.75, 2.05) | 1.13 (0.69, 1.86) | 1.71 (0.99, 3.03) | |
| hs-Troponin T (>= 14 ng/L) | 1.74 (1.07, 2.83) | 1.04 (0.66, 1.65) | 2.85 (1.51, 5.37) | |
| Pulmonary function: | ||||
| % predicted FVC | 0.98 (0.97, 1.00) | 1.01 (1.00, 1.01) | 0.99 (0.98, 1.00) | |
| % predicted FVC/FEV1 | 0.99 (0.98, 1.01) | 1.01 (1.00, 1.03) | 0.99 (0.98, 1.01) | |
| Depressive Symptoms | 1.77 (1.53, 2.10) | 1.35 (1.20, 1.52) | 1.26 (1.12, 1.42) |
Odds ratios (OR) are represented as OR (95% CI) and are from multinomial latent class regression accounting for most likely class membership classification error. Sample size is estimated based on most likely subtype membership. Abbreviations: OR = odds ratio; CNS = central nervous system; NT-proBNP= N-terminal prohormone of brain natriuretic peptide; hs-troponin T = high sensitivity cardiac troponin T; ADI = area deprivation index; BMI = body mass index; sCr = serum creatinine; eGFR = estimated glomerular filtration rate, mmHg = millimeters of mercury; FVC = forced vital capacity; FVC/FEV1 = Forced vital capacity to Forced expiratory volume in 1 second ratio.