Table 2:

Time-specific vital signs and laboratory values during first 24 hours following initiation of transfusion for trauma patients undergoing UMT stratified by mortality

Model		Overall	Overall Survival			48-hour Survival
Time Interval	Variable		Deceased	Survivors	p-value	Deceased	Survivor	p-value
0-2 hours		n = 180	n = 94	n = 86		n = 72	n = 107
	Heart Rate	120 [98, 137]	119 [89, 137]	123 [104, 136]	0.177	114 [86, 134]	125 [106, 138]	0.018*
	SBP	94 [84, 109]	96 [82, 108]	93 [84, 110]	0.964	96 [85, 112]	93 [84, 107]	0.455
	Lactate	10.8 [7.5, 14.5]	13.7 [8.2, 15.7]	10.2 [5.2, 12.4]	0.126	14 [13.3, 15.7]	10 [6.8, 12.7]	0.461
	Base Deficit	−16.8 [−21.5, −11.4]	−20 [−25.0, −13.0]	−16 [−19.0, −10.8]	0.215	−20 [−25, −13]	−16 [−19, −10.8]	0.215
	pH	7.0 [6.9, 7.2]	6.9 [6.8, 7.1]	7.1 [7.0, 7.2]	0.077	6.9 [6.8, 7.1]	7.1 [7, 7.2]	0.077
	Hemoglobin	12 [10.7, 13.2]	11.7 [10.4, 12.6]	12.1 [11.1, 13.5]	0.208	11.6, [10.1, 12.4]	12.2 [11.1, 13.3]	0.027*
	Platelets	206 [151, 239]	187 [134, 245]	206 [173, 227]	0.810	151 [120, 209]	217 [175, 247]	0.001*
2-4 hours		n = 180	n = 92	n = 86		n = 71	n = 106
	Heart Rate	105 [96, 127]	113 [103, 128]	104 [83,127]	0.143	113 [104, 128]	103 [84, 127]	0.284
	SBP	111 [104, 121]	108 [98, 116]	115 [110, 121]	0.243	113 [104, 120]	111 [105, 121]	0.677
	Lactate	10 [7.2, 16.2]	12.6 [9.5, 25.0]	7.5 [5.3, 10.0]	0.063	18.8 [12.5, 25]	9.8 [6.5, 14.4]	0.415
	Base Deficit	−11.8 [−17.0, −5.0]	−14.3 [−17.0, −8.4]	−7.0 [−14.0, −3.0]	0.033*	−15.5 [−18.2, −10.2]	−8 [−13.5, −4.0]	0.006*
	pH	7.2 [7.0, 7.3]	7.1 [7.0, 7.2]	7.2 [7.2, 7.3]	0.012*	7.1 [7.0, 7.1]	7.2 [7.2, 7.3]	0.004*
	Hemoglobin	10.7 [9.7, 12.6]	10.5 [9.6, 12.2]	11.1 [10.2, 13.1]	0.941	10.4 [8.7, 12.2]	10.9 [10.3, 12.6	0.848
	Platelets	149 [82, 251]	86 [59, 148]	199 [141, 312]	0.003*	78 [59, 117]	179 [137, 280]	0.013*
4-8 hours		n = 180	n = 83	n = 86		n = 62	n = 107
	Heart Rate	113 [91, 129]	117 [96, 130]	110 [85, 127]	0.038*	117 [101, 130]	111 [87, 128]	0.032*
	SBP	117 [102, 136]	107 [93, 127]	126 [110, 141]	< 0.001*	102 [91, 117]	127 [109, 140]	< 0.001*
	Lactate	8.0 [5.0, 15.1]	14.6 [8.5, 16.5]	5.2 [3.8, 7.7]	< 0.001*	15.2 [9.4, 17.1]	5.4 [4, 10]	< 0.001*
	Base Deficit	−7.2 [−11.4, −1.8]	−9.8 [−15, −5.8]	−3 [−8.4, 0.6]	< 0.001*	−13 [--16.8, −8.3]	−3.5 [−8.5, −0.6]	< 0.001*
	pH	7.2 [7.1, 7.4]	7.2 [7.0, 7.2]	7.2 [7.1, 7.4]	< 0.001*	7.1 [7.0, 7.2]	7.3 [7.2, 7.4]	< 0.001*
	Hemoglobin	10.6 [9.5, 12.2]	9.7 [8.6, 10.9]	11.7 [10.2, 13.1]	0.011*	9.5 [8.2, 10.5]	11.6 [10.2, 12.9]	0.032*
	Platelets	65 [42, 86]	59 [36, 80]	73 [50, 88]	0.073	62 [34, 77]	67 [48, 88]	0.076*
8-12 hours		n = 180	n = 56	n = 86		n = 35	n = 107
	Heart Rate	111[99, 126]	118 [100,131]	110 [99, 121]	0.099	123 [112, 132]	109 [97, 122]	0.080*
	SBP	117 [102, 131]	106 [98, 126]	121 [107, 132]	0.009	102 [85, 117]	121 [105, 133]	0.001*
	Lactate	7.2 [4.0, 12.1]	12.2 [9.1, 14.7]	5.1 [3.2, 8.1]	< 0.001*	13.2 [9.8, 16.9]	5.6 [3.4, 9.4]	< 0.001*
	Base Deficit	−3.8 [−8.9, −0.6]	−9.4 [−14, −3.7]	−1.9 [−4.9, −1.2]	< 0.001*	−11.2 [−15, −6]	−2.2 [−4.9, −0.1]	< 0.001*
	pH	7.3 [7.2, 7.4]	7.1 [7.1, 7.3]	7.3 [7.3, 7.4]	< 0.001*	7.1 [7.1, 7.3]	7.3 [7.3, 7.4]	< 0.001*
	Hemoglobin	10.9 [8.9, 12.4]	10.1 [8.2, 11.5]	11.1 [10, 12.8]	0.013*	9.3 [8.2, 11.2]	11.1 [9.7, 12.8]	0.007*
	Platelets	61 [42, 79]	53 [30, 71]	66 [51, 81]	0.027*	42 [27, 59]	67 [51, 83]	< 0.001*
12-16 hours		n = 180	n = 41	n = 86		n = 20	n = 107
	Heart Rate	112 [98, 125]	118 [108, 127]	109 [95, 122]	0.016*	119 [106, 127]	111 [97, 124]	0.406
	SBP	117 [102, 130]	108 [99, 122]	119 [106, 130]	0.047*	105 [99, 119]	117 [104, 130]	0.182
	Lactate	4.9 [3.2, 8.2]	9.9 [7.6, 13.4]	3.6 [2.9, 5.8]	< 0.001*	13.3 [10.6, 18.2]	3.8 [3.0, 6.9]	< 0.001*
	Base Deficit	−1.4 [−5.4, 1.6]	−5.3 [−8.2, −1.6]	0 [−3.0, 2.0]	0.139	−7.2 [−13.0, −5.0]	−0.8 [−3.0, 1.7]	0.351
	pH	7.4 [7.3, 7.4]	7.3 [7.1, 7.4]	7.4 [7.3, 7.4]	0.019*	7.2 [7.1, 7.4]	7.4 [7.3, 7.4]	0.086
	Hemoglobin	11.3 [9.9, 12.9]	10.3 [9, 11.8]	11.5 [10.3, 13.2]	0.007*	9.1 [7.9, 11.6]	11.4 [10.1, 12.9]	0.002*
	Platelets	66 [50, 86]	51 [35, 66]	71 [56, 96]	0.009*	51 [39, 55]	68 [55, 93]	0.001*
16-20 hours		n = 180	n = 34	n = 86		n = 13	n = 106
	Heart Rate	112 [97, 123]	114 [104, 132]	109 [91, 121]	0.023*	116 [107, 130]	111 [95, 122]	0.167
	SBP	113 [105, 126]	116 [106, 130]	113 [105, 125]	0.718	115 [99, 120]	113 [106, 127]	0.351
	Lactate	5.8 [3, 8.5]	8.3 [7.1, 12.8]	3.5 [2.6, 6]	< 0.001*	13.1 [8.1, 15.9]	5.3 [2.8, 7.7]	0.003*
	Base Deficit	−0.4 [−5.5, 1.4]	−5.1 [−8, −1.5]	0.5 [−3.2, 2.2]	< 0.001*	−6.4 [−11.4, −0.3]	−0.1 [−4.2, 1.6]	0.018*
	pH	7.4 [7.3, 7.4]	7.3 [7.2, 7.4]	7.4 [7.3, 7.4]	< 0.001*	7.3 [7.1, 7.4]	7.4 [7.3, 7.4]	0.064
	Hemoglobin	10.9 [9.9, 12.6]	10.2 [8.7, 11.8]	11.1 [10.2, 12.7]	0.011*	9.9 [9.2, 11.5]	11.0 [10.1, 12.6]	0.078
	Platelets	69 [45, 92]	44 [37, 83]	76 [59, 96]	0.047*	43 [40, 45]	72 [57, 98]	0.001*
20-24 hours		n = 180	n = 31	n = 86		n = 10	n = 107
	Heart Rate	110 [94, 120]	108 [99, 129]	113 [91, 119]	0.008*	117 [108, 135]	109 [92, 120]	0.046*
	SBP	112 [105, 127]	108 [99, 129]	113 [107, 127]	0.630	103 [99, 129]	113 [106, 127]	0.244
	Lactate	4.4 [3.3, 7.2]	7.6 [5.4, 10.1]	4 [3, 4.8]	0.001*	12.6 [8.2, 17.2]	4.3 [3.2, 6.5]	0.067
	Base Deficit	−0.7 [−5, 1.8]	−5 [−8.8, −0.3]	0.0 [−2.9, 2.4]	0.001*	−8.8 [−11.0, −6.1]	−0.6 [−2.9, 2.0]	0.001*
	pH	7.4 [7.3, 7.4]	7.3 [7.2, 7.4]	7.4 [7.4, 7.4]	0.019*	7.2 [7.2, 7.3]	7.4 [7.3, 7.4]	0.014*
	Hemoglobin	11.1 [9.6, 12.8]	10.4 [9.5, 12.1]	11.6 [10.1, 12.8]	0.443	10.0 [7.5, 10.8]	11.6 [9.8, 12.8]	0.037*
	Platelets	65 [52, 90]	46 [37, 67]	68 [58, 94]	< 0.001*	32 [22, 45]	67 [56, 91]	< 0.001*

Systolic blood pressure (SBP), not applicable (n/a). Continuous variables reported as median with [Q1, Q3]