Table 2.
Comparison of AVS, cross-sectional imaging, and aldosterone driver mutations of study participants, stratified by post-operative biochemical outcomes.
| PA cure (220) | Partial improvement (34) | No improvement (29) | p value | |
|---|---|---|---|---|
| AVS Lateralization a | ||||
| LL | 161 (73,2%) | 15 (46.9%) | 7 (33.3%) | <0.0001 |
| LB | 11 (5.0%) | 9 (28.1%) | 11 (52.4%) | |
| BL | 36 (16.4%) | 4 (12.5%) | 3 (14.4%) | |
| FL | 12 (5.5%) | 4 (12.5%) | 0 (0 %) | |
| CT findings b | ||||
| Ipsilateral nodule | 165 (79.7%) | 20 (58.8%) | 11 (37.9%) | <0.0001 |
| Contralateral nodule | 7 (3.4%) | 1 (2.9%) | 3 (10.3%) | |
| Bilateral | 9 (4.3%) | 2 (5.9%) | 6 (20.7%) | |
| No nodule | 26 (12.6%) | 11 (32.4%) | 9 (31.0%) | |
| Aldosterone-driver mutation c | ||||
| CACNA1D | 41 (33.1%) | 10 (58.8%) | 9 (69.2%) | 0.0035 |
| KCNJ5 | 52 (41.9%) | 5 (29.4%) | 3 (23.1%) | |
| ATPase | 31 (25.0%) | 2 (11.8%) | 1 (7.7%) | |
AVS results were classified as lateralized (L) or bilateral (B) based on lateralization indices ≥4 or <4, respectively. Baseline (first letter) and cosyntropin-stimulated (second letter) AVS results are shown. F stands for failed adrenal vein cannulation. Patients from Munich University (7) had AVS only without cosyntropin stimulation, and patients from University of Pennsylvania (3) had AVS only without cosyntropin stimulation, and they were not included in this table.
Cross-sectional imaging data was not available in 13 patients with PA cure.
In cases with multiple CYP11B2-positive areas, DNA sequencing was performed on the dominant lesions.