Table 2.
Association of plasma sphingolipids with HOMA2-%S and oral disposition index
| ln (HOMA2-%S) at baseline | ln (DIo) at baseline | |||||
|---|---|---|---|---|---|---|
| β-coefficient (95% CI) | P value | Q value† | β-coefficient (95% CI) | P value | Q value† | |
| lnCer-C16:0 | −0.201 (−0.362, −0.041) | 0.014 | 0.035 | −0.301 (−0.582, −0.020) | 0.036 | 0.133 |
| lnCer-C18:0 | −0.144 (−0.245, −0.043) | 0.005 | 0.017 | −0.038 (−0.216, 0.197) | 0.670 | 0.931 |
| lnCer-C20:0 | −0.208 (−0.326, −0.091) | 0.001 | 0.010 | −0.198 (−0.408, 0.011) | 0.063 | 0.157 |
| lnCer-C22:0 | −0.194 (−0.315, −0.074) | 0.002 | 0.010 | −0.222 (−0.434, −0.011) | 0.040 | 0.133 |
| lnGluCer-C22:0 | −0.042 (−0.153, 0.069) | 0.463 | 0.514 | 0.103 (−0.091, 0.299) | 0.297 | 0.594 |
| lnGluCer-C24:0 | −0.072 (−0.189, 0.038) | 0.215 | 0.275 | −0.004 (−0.202, 0.194) | 0.969 | 0.969 |
| lnLacCer-C16:0 | 0.076 (−0.045, 0.197) | 0.220 | 0.275 | 0.018 (−0.194, 0.231) | 0.868 | 0.964 |
| lnSM-C16:0 | 0.196 (0.018, 0.374) | 0.031 | 0.052 | −0.051 (−0.365, 0.261) | 0.745 | 0.931 |
| lnSM-C18:0 | −0.051 (−0.245, 0.143) | 0.607 | 0.607 | −0.120 (−0.460, 0.219) | 0.487 | 0.811 |
| lnSM-C20:0 | −0.226 (−0.441, −0.023) | 0.029 | 0.052 | −0.401 (−0.766, −0.032) | 0.031 | 0.133 |
| ln (Change of HOMA2-%S)* | ln (Change of DIo)** | |||||
| β-coefficient (95% CI) | P value | Q value† | β-coefficient (95% CI) | P value | Q value† | |
| lnCer-C16:0 | −0.189 (−0.318, −0.061) | 0.004 | 0.010 | −0.028 (−0.085, 0.029) | 0.314 | 0.628 |
| lnCer-C18:0 | −0.188 (−0.267, −0.108) | <0.001 | <0.003 | −0.021 (−0.057, 0.015) | 0.260 | 0.628 |
| lnCer-C20:0 | −0.160 (−0.257, −0.064) | 0.001 | 0.003 | −0.025 (−0.068, 0.017) | 0.241 | 0.628 |
| lnCer-C22:0 | −0.173 (−0.270, −0.076) | <0.001 | <0.003 | −0.013 (−0.055, 0.031) | 0.567 | 0.652 |
| lnGluCer-C22:0 | −0.068 (−0.156, 0.021) | 0.136 | 0.194 | 0.014 (−0.025, 0.054) | 0.446 | 0.650 |
| lnGluCer-C24:0 | −0.047 (−0.138, 0.044) | 0.309 | 0.354 | 0.006 (−0.034, 0.046) | 0.778 | 0.778 |
| lnLacCer-C16:0 | −0.027 (−0.124, 0.071) | 0.591 | 0.591 | 0.033 (−0.010, 0.076) | 0.135 | 0.628 |
| lnSM-C16:0 | 0.147 (0.003, 0.290) | 0.045 | 0.075 | 0.070 (0.007, 0.134) | 0.030 | 0.300 |
| lnSM-C18:0 | −0.167 (−0.322, −0.012) | 0.035 | 0.070 | −0.020 (−0.089, 0.050) | 0.587 | 0.652 |
| lnSM-C20:0 | −0.086 (−0.256, 0.084) | 0.319 | 0.354 | −0.029 (−0.104, 0.046) | 0.455 | 0.650 |
Model was adjusted for age, sex, BMI, LDL-C, physical activity and smoking status.
*, **
Additionally adjusted for baseline *HOMA2-S or **DIo.
†
Corrected for multiple comparison with Benjamini–Hochberg method (with FDR of 0.05).
HOMA2-S, homeostasis model assessment of insulin sensitivity; DIo, oral disposition index; BMI, body mass index; LDL-C, low density lipoprotein-cholesterol; FDR, false discovery rate; Cer, ceramide; GluCer, glucosylceramide; LacCer, lactosylceramide; SM, sphingomyelin.