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. Author manuscript; available in PMC: 2025 Feb 19.
Published in final edited form as: Chem Res Toxicol. 2024 Jan 9;37(2):340–360. doi: 10.1021/acs.chemrestox.3c00333

Figure 1.

Figure 1.

Identification of DNA adducts using wide-SIM/MS2 and wSIM-City. (A) Mechanism of 2′-deoxyribose loss of the modified DNA nucleoside under HCD. (B) Scanning method for detecting DNA adducts by high-resolution mass spectrometry (HRMS) showing multiple MS1 and MS2 isolation windows utilized for each duty cycle. (C) A scheme for the wSIM-City algorithm and (D) wSIM-City performing neutral loss search for 2′-deoxyribose loss and subsequent plotting of precursor [M+H]+ and aglycone [BH2]+ ions.