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. Author manuscript; available in PMC: 2025 Feb 19.
Published in final edited form as: Chem Res Toxicol. 2024 Jan 9;37(2):340–360. doi: 10.1021/acs.chemrestox.3c00333

Figure 6.

Figure 6.

Wide-SIM/MS2 EICs and wSIM-City identification of 3-NBA DNA adducts in the kidney of untreated and rats treated with the 13-carcinogen mixture 24 h post-dosing. The precursor ions are shown in black, and the aglycone ions are depicted in red. The arrows at tR 25.00 and 25.78 min show where synthetic dG-N2-3-ABA and dG-C8-C2–3-ABA elute. The base peak at tR 25.08 min is the retention time of synthetic dG-C8-N-3-ABA. The major peak is the proposed dA-N6-3-ABA adduct at tR 27.02 min. The minor peak dA adduct at tR 24.90 min is tentatively assigned as dA-C8-N-3-ABA. The EIC data are from wSIM-City automated identification of the precursor and aglycone m/z peak intensities within a 5 ppm mass tolerance.