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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Nat Rev Genet. 2023 Nov 8;25(3):196–210. doi: 10.1038/s41576-023-00663-0

Fig. 5. Mechanisms through which chromothripsis drives tumorigenesis.

Fig. 5.

Three chromothripsis-associated mechanisms are thought to be capable of driving tumorigenesis: 1) disruption or loss of tumor suppressors, 2) generation of oncogenic fusions, and 3) amplification of oncogenes, with the most prevalent pathway being through the generation of circular, self-propagating and oncogene-bearing extrachromosomal DNA (ecDNA). Chromothripsis-affected genes, identified in patient-derived tumors, are listed for each mechanism.