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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Nat Rev Genet. 2023 Nov 8;25(3):196–210. doi: 10.1038/s41576-023-00663-0

Fig. 6. Pan-cancer genome analysis reveals frequent co-occurrence of chromo-thripsis and ecDNA in 25 cancer types.

Fig. 6.

Left, blue: percentages of chromothripsis-positive samples per cancer type are from Cortes-Ciriano et al., Nat Genet 2020; descending from top to bottom. Right, red: percentages of ecDNA-positive samples per cancer type are from Kim et al., Nat Genet 2020. Cancer types, similar or matching between the two studies are shown. Fractions show the number of chromothripsis-positive (left, blue) or ecDNA-positive (right, red) samples per total number of samples analyzed per given cancer type in the corresponding study. Left (blue): the cancer types abbreviations (top to bottom) are: SoftTissue-Liposarc, liposarcoma, soft tissue; CNS-GBM, central nervous system glioblastoma; Eso-AdenoCA, esophagus adenocarcinoma; Skin-Melanoma, skin melanoma; Lung-AdenoCA, lung adenocarcinoma; Breast-AdenoCA, breast adenocarcinoma; Prost-AdenoCA, prostate adenocarcinoma; Lung-SCC, lung squamous cell carcinoma; Panc-AdenoCA, pancreatic adenocarcinoma; Ovary-AdenoCA, ovary adenocarcinoma; Stomach-AdenoCA, stomach adenocarcinoma; Biliary-AdenoCA, biliary adenocarcinoma; Bladder-TCC, bladder transitional cell carcinoma; Kidney-RCC, kidney renal cell carcinoma; ColoRect-AdenoCA, colorectal adenocarcinoma; Liver-HCC, liver hepatocellular carcinoma; Bone-Epith, bone neoplasm, epithelioid; Cervix-SCC, cervix squamous cell carcinoma; Lymph-BNHL, lymphoid mature B-cell lymphoma; Head-SCC, head-and-neck squamous cell carcinoma; CNS-Medullo, CNS medulloblastoma; Thy-AdenoCA, thyroid low-grade adenocarcinoma; Lymph-CLL, lymphoid chronic lymphocytic leukemia; Myeloid-MDS, myeloid myelodysplastic syndrome; Myeloid-MPN, myeloid myeloproliferative neoplasm; Myeloid-AML, myeloid acute myeloid leukemia.