Table 3:
Sepsis/Pneumonia vs. other ARDS etiologies
| 28-Day Mortality | ||||||||
|---|---|---|---|---|---|---|---|---|
| ARDS Etiologies | Metabolic, No. (%) | Control, No. (%) | Unadjusted OR (95% CI) | Adjusted ORa(95% CI) | P-valuec | Unadjusted Interaction P-valued | Adjusted Interaction P-valued | |
| Sepsis/Pneumonia | 82 (22.5) | 783 (27.6) | 0.76 (0.59–0.99) | 0.64 (0.48–0.84) | 0.001 | 0.02 | 0.04 | |
| Other Etiologies | 24 (26.7) | 194 (19.5) | 1.50 (0.92–2.45) | 1.18 (0.70–1.99) | 0.546 | |||
| 90-Day Mortality | ||||||||
| ARDS Etiologies | Metabolic, No. (%) | Control, No. (%) | Unadjusted OR (95% CI) | Adjusted ORa (95% CI) | P-valuec | Unadjusted Interaction P-valued | Adjusted Interaction P-valued | |
| Sepsis/Pneumonia | 103 (28.3) | 919 (32.4) | 0.83 (0.65–1.05) | 0.69 (0.53–0.89) | 0.005 | <0.01 | 0.02 | |
| Other Etiologies | 31 (34.4) | 237 (23.9) | 1.68 (1.06–2.65) | 1.26 (0.77–2.06) | 0.366 | |||
a
Multivariable logistic regression model adjusted for age, sex, race, ethnicity, comorbidities, and treatment group assignment.
b
Other ARDS etiologies include all primary etiologies other than sepsis or pneumonia.
c
P-value for adjusted analyses comparing metabolic to control.
d
P-values for comparing the interaction between metabolic and control across the two ARDS etiology strata of sepsis/pneumonia and other ARDS etiology. OR=Odds Ratio.