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. Author manuscript; available in PMC: 2025 Mar 1.
Published in final edited form as: J Thromb Haemost. 2023 Nov 24;22(3):620–632. doi: 10.1016/j.jtha.2023.11.008

Figure 4. Plasma fibrinogen and FXIII in mice and humans after PHx.

Figure 4.

Male wild-type mice underwent 2/3rd partial hepatectomy (PHx), 90% extended PHx, or sham surgery (see Methods) and plasma was collected 30 minutes after the last lobe was resected. (A) Plasma fibrinogen concentration was determined by ELISA (see Methods). (B) Plasma fibrinogen concentration was determined by ELISA (see Methods) in plasma samples collected from 88 patients one day prior to surgery as well as on postoperative day 1 (POD1) and 5 days (POD5) after liver resection. Liver dysfunction (LD) at 90 days post-op was determined using ISGLS criteria (see Methods). (C) Plasma FXIII-A antigen levels in mice after PHx was determined using capillary-based western blotting. Representative samples are shown in a digital capillary rendering. (D) Plasma FXIII-A activity was determined in 88 patients as above for fibrinogen (see Methods). For A and C, results from individual mice are plotted and bars represent mean ± standard error of mean. N=5–10 mice per group. *P<0.05, ***P<0.001. For B and D, results from 88 patients are expressed as Tukey box and whisker plot. *P<0.05, **P<0.01, ***P<0.001., ****P<0.0001.