Table 2.

Advantages and Disadvantages of Proposed Approach

Advantages	Disadvantages
Mimics animal models of OA where successful treatments have been identified.	Does not necessarily meet regulatory requirements in terms of pain or structure outcomes.
May identify treatment for high risk subgroup who suffer for many years with pain	May not identify treatment for older onset OA
Data suggests sample size for trial achieveable if high risk patients selected	Actual trial needed to show high risk patients have sufficient number of outcomes to test treatments