Table 2.
The association between marital status and all-cause mortality overall and stratified by disease state, age, and continent of enrollment in IRONMAN (N=2,119), 2017–2023a
| Deaths, n | Married | Not Married | |
|---|---|---|---|
| Overall (age adjusted only) | 427 (Married: n=333 Not Married: n=94) |
1.00 (ref) | 1.07 (0.85, 1.35) |
| Overall (fully adjusted) b | 1.00 (ref) | 1.44 (1.02, 2.02) | |
| Disease state | |||
| mHSPC (n = 1,401) | 209 | 1.00 (ref) | 1.63 (1.05, 2.53) |
| CRPC (n = 718) | 218 | 1.00 (ref) | 1.14 (0.65, 2.00) |
| Age group (in years) | |||
| <70 (n = 956) | 175 | 1.00 (ref) | 1.11 (0.64, 1.93) |
| ≥70 (n = 1,163) | 252 | 1.00 (ref) | 1.67 (1.08, 2.59) |
| Continent of enrollment | |||
| North America (n = 976) | 203 | 1.00 (ref) | 1.79 (1.09, 2.92) |
| Europe (n = 875) | 162 | 1.00 (ref) | 1.19 (0.66, 2.16) |
| Other (n = 268) | 62 | 1.00 (ref) | 1.48 (0.63, 3.47) |
Abbreviations: IRONMAN, International Registry for Men with Advanced Prostate Cancer; mHSPC, Metastatic hormone-sensitive prostate cancer; CRPC, Castration resistant prostate cancer.
Hazard ratios (HR) and 95% confidence intervals obtained from Cox proportional hazards model.
Adjusted for living arrangement (living alone vs. not living alone), age at enrollment (continuous), disease state (mHSPC vs. CRPC), continent of enrollment (North America, Europe, and other), self-reported race (white vs. non-white), employment status (not working vs. currently working), smoking status (current non-smoker vs. current smoker), family history of prostate cancer (yes vs. no), and PSA at enrollment (continuous).