Table 3.
The associations between marital status and living arrangements jointly categorized and all-cause mortality overall and stratified by disease state, age, and continent of enrollment in IRONMAN (N=2,119), 2017–2023a
| Deaths, n | Married | Not married, Living alone | Not married, Not living alone | |
|---|---|---|---|---|
| Overall (age adjusted only) | 427 | 1.00 (ref) | 0.96 (0.73, 1.26) | 1.38 (0.96, 1.97) |
| Overall (fully adjusted) b | 427 | 1.00 (ref) | 0.96 (0.73, 1.26) | 1.41 (0.98, 2.02) |
| Disease state | ||||
| mHSPC (n = 1,401) | 209 | 1.00 (ref) | 0.92 (0.61, 1.36) | 1.61 (1.01, 2.55) |
| CRPC (n = 718) | 218 | 1.00 (ref) | 0.95 (0.64, 1.39) | 1.12 (0.62, 2.03) |
| Age group (in years) | ||||
| <70 (n = 956) | 175 | 1.00 (ref) | 0.73 (0.46, 1.16) | 1.02 (0.56, 1.86) |
| ≥70 (n = 1,163) | 252 | 1.00 (ref) | 1.11 (0.79, 1.57) | 1.70 (1.08, 2.67) |
| Continent of enrollment | ||||
| North America (n = 976) | 203 | 1.00 (ref) | 0.95 (0.63, 1.44) | 1.80 (1.08, 2.99) |
| Europe (n = 875) | 162 | 1.00 (ref) | 1.17 (0.78, 1.75) | 1.14 (0.59, 2.18) |
| Other (n = 268) | 62 | 1.00 (ref) | 0.46 (0.16, 1.28) | 1.46 (0.61, 3.48) |
Abbreviations: IRONMAN, International Registry for Men with Advanced Prostate Cancer; mHSPC, Metastatic hormone-sensitive prostate cancer; CRPC, Castration resistant prostate cancer.
Hazard ratios (HR) and 95% confidence intervals obtained from Cox proportional hazards model.
Adjusted for age at enrollment (continuous), disease state (mHSPC vs. CRPC), continent of enrollment (North America, Europe, and other), self-reported race (white vs. non-white), employment status (not working vs. currently working), smoking status (current non-smoker vs. current smoker), family history of prostate cancer (yes vs. no), and PSA at enrollment (continuous).