Table 4.
Sensitivity analyses with alternative categorization of marital status, expanded list of covariate adjustment, and modifying follow up time in IRONMAN (N=2,119), 2017–2023a
| Deaths, n | Married | Not Married | |
|---|---|---|---|
| Main analysis (Overall, fully adjustedb) | 427 | 1.00 (ref) | 1.44 (1.02, 2.02) |
| Categorical marital status (n = 2,119) | 427 | — | — |
| Divorced/separated (n = 222) | 43 | 1.00 (ref) | 1.30 (0.87, 1.94) |
| Widowed (n = 123) | 33 | 1.00 (ref) | 1.89 (1.22, 2.94) |
| Never married (n = 107) | 18 | 1.00 (ref) | 1.18 (0.67, 2.05) |
| Additionally adjusting for Education, Gleason score, and ECOG (Binary) (n = 1,489) | 284 | 1.00 (ref) | 1.49 (0.97, 2.22) |
Abbreviations: IRONMAN, International Registry for Men with Advanced Prostate Cancer; ECOG, Eastern Cooperative Oncology Group.
Hazard ratios (HR) and 95% confidence intervals obtained from Cox proportional hazards model.
Adjusted for living arrangement (living alone vs. not living alone), age at enrollment (continuous), disease state (mHSPC vs. CRPC), continent of enrollment (North America, Europe, and other), self-reported race (white vs. non-white), employment status (not working vs. currently working), smoking status (current non-smoker vs. current smoker), family history of prostate cancer (yes vs. no), and PSA at enrollment (continuous).