Table 2.
Binding affinities of produced FcγRs and comparison with reported values (nM)
IgG wt | IgG carrying Fc mutation | ||||
---|---|---|---|---|---|
This study | Literature (Ref) | Mutant | This study | Literature (Ref) | |
FcγRIIa-131H | 290 ± 67 | 292[24]; 800[25] | GA | 120 ± 35 | 130 ± 10[26] |
FcγRIIa-131R | 610 ± 260 | 203[24]; 800[25] | GA | 210 ± 109 | 161 ± 3[26] |
FcγRIIb | 360 ± 53 | 1274[24]; 3100[25] | PD | 310 ± 42 | N/A |
FcγRIIIa-176F | 47 | 502[24]; 850[25] | LPL | 110 | N/A |
FcγRIIIa-176V | 610 ± 39 | 554[24]; 850[25] | LPL | 250 ± 57 | N/A |