Table 2:
Week 2 AUC24, log10Cmax, log10Cmin and log10 Clearance. Mean differences by ABCG2 and NR1I2 genotype (Dominant Model). Adjustment variables included drug formulation cohort, weight, and sex.
| Regression Model | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted | ||||||||
| Genotype | PK Parameter | Gene Levels | n | Mean Difference | CI | P-value | Mean Difference | CI | P-value |
|
| |||||||||
| ABCG2 | AUC24(μg*h/mL) | C/C | 46 | ||||||
| A/A or C/A | 12 | −12.80 | (−28.29, 2.69) | 0.11 | −15.69 | (−31.97, 0.58) | 0.06 | ||
| Cmax(μg/mL) | C/C | 46 | |||||||
| A/A or C/A | 12 | −0.13 | (−0.22, −0.03) | 0.010 | −0.15 | (−0.25, −0.05) | 0.003 | ||
| Cmin(μg/mL) | C/C | 46 | |||||||
| A/A or C/A | 12 | −0.14 | (−0.34, 0.06) | 0.17 | −0.17 | (−0.36, 0.02) | 0.09 | ||
| log Clearance (L/hr) | C/C | 47 | |||||||
| A/A or C/A | 12 | 0.06 | (−0.14, 0.26) | 0.54 | 0.10 | (−0.03, 0.23) | 0.13 | ||
| NR1I2 | AUC24(μg*h/mL) | C/C | 21 | ||||||
| T/T or C/T | 37 | 11.63 | (−1.38, 24.64) | 0.08 | 11.92 | (−1.14, 24.99) | 0.07 | ||
| Cmax(μg/mL) | C/C | 21 | |||||||
| T/T or C/T | 37 | 0.05 | (−0.04, 0.13) | 0.27 | 0.05 | (−0.03, 0.14) | 0.22 | ||
| Cmin(μg/mL) | C/C | 21 | |||||||
| T/T or C/T | 37 | 0.11 | (−0.06, 0.28) | 0.20 | 0.11 | (−0.04, 0.27) | 0.16 | ||
| log Clearance (L/hr) | C/C | 22 | |||||||
| T/T or C/T | 37 | −0.03 | (−0.19, 0.14) | 0.77 | −0.08 | (−0.18, 0.02) | 0.14 | ||