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. Author manuscript; available in PMC: 2025 Mar 1.
Published in final edited form as: J Acquir Immune Defic Syndr. 2024 Mar 1;95(3):297–303. doi: 10.1097/QAI.0000000000003358

Table 4:

Genotype differences for time-averaged AUC24 log10 plasma HIV RNA and CD4+ cell count.

Time-Average AUC
Log10 HIV RNA-load CD4 Count
Genotype Gene Level n Estimate 95% CI P-value n Estimate 95% CI P-value
ABCG2 C/C 43 46
A/A or C/A 10 0.00 (−0.46, 0.47) 0.99 9 −86.90 (−787.24, 613.44) 0.79
NR1I2 C/C 20 21
T/T or C/T 33 0.17 (−0.36, 0.70) 0.51 34 132.59 (−325.13, 590.31) 0.56
UGT1A1 (Model 1) Intermediate 13 13
Extensive 36 −0.44 (−0.82, −0.06) 0.024 37 95.19 (−423.18, 613.56) 0.71
Poor 4 −0.09 (−0.43, 0.25) 0.57 5 124.39 (−653.00, 901.79) 0.73
UGT1A1 (Model 2) Extensive/Intermediate 49 50
Poor 4 0.24 (−0.13, 0.60) 0.19 5 53.00 (−685.92, 793.82) 0.86

P-values and 95% Confidence intervals were computed using a two-sample t-test for the differences in mean