Table 4:

Associations of hearing loss exposures with baseline FDG-PET neuroimaging outcomes

	PE (95% CI)*	P-value*
Hearing Loss Exposures	Anterior Cingulate Cortex in SUVR
PTA as continuous (10-dB HL increase)	−0.002 (−0.011 to 0.006)	0.5
PTA ≥40 vs <40 dB HL	−0.013 (−0.035 to 0.010)	0.3
PTA >25 vs ≤25 dB HL	0.004 (−0.017 to 0.025)	0.7
WRS as continuous (10% decrease)	−0.013 (−0.021 to −0.005)	0.001
WRS <90 vs ≥90%	−0.018 (−0.040 to 0.003)	0.09
WRS <100 vs 100%	−0.008 (−0.027 to 0.010)	0.4
Informant-based hearing difficulties (yes vs no)	−0.012 (−0.030 to 0.006)	0.2

^*PEs, 95% CIs, and p-values from multivariable linear regression models adjusted for age, sex, years of education, smoking status, diabetes, hypertension, APOE ε4 carriership, and hearing rehabilitation. Higher values of anterior cingulate cortex are considered more favorable.

APOE=apolipoprotein E; dB HL=decibels hearing level; FDG-PET=fluorodeoxyglucose-positron emission tomography; PE=parameter estimate; PTA=pure tone average; SUVR=standard uptake value ratio; WRS=word recognition score