Table 4.

Performance of clinical scores to predict advanced liver fibrosis (VCTE ≥ 9.7 kPa) and cirrhosis (VCTE ≥ 13.6 kPa) among different racial/ethnic groups in patients between 35 and 64 years old.

	Hispanic	Non-Hispanic White	Non-Hispanic Black	Non-Hispanic Asian	p value#	Entire cohort
Advanced Fibrosis (F3–4 vs. F0–2)
FIB-4	0.61 (0.51–0.70)	0.51 ^ (0.43–0.60)	0.48 ^ (0.38–0.58)	0.72 (0.57–0.86)	0.029	0.55 (0.49–0.60)
APRI	0.63 (0.54–0.73)	0.57 ^ (0.48–0.65)	0.46 @,^ (0.37–0.55)	0.74 (0.60–0.89)	0.005	0.57 (0.52–0.62)
NFS	0.79 (0.73–0.86)	0.78 (0.71–0.84)	0.70 (0.60–0.79)	0.81 (0.70–0.93)	0.37	0.76 (0.72–0.80)
p value*	<0.001	<0.001	<0.001	0.38		<0.001
Cirrhosis (F4 vs. F0–3)
FIB-4	0.70 (0.57–0.84)	0.57 ^ (0.43–0.71)	0.44 @,^ (0.26–0.63)	0.88 @ (0.80–0.96)	<0.001	0.60 (0.51–0.69)
APRI	0.63 (0.48–0.79)	0.60 ^ (0.47–0.74)	0.46 ^ (0.30–0.62)	0.84 @ (0.73–0.95)	<0.001	0.60 (0.51–0.68)
NFS	0.85 (0.77–0.93)	0.85 (0.77–0.92)	0.82 (0.67–0.97)	0.86 (0.69–1.00)	0.99	0.84 (0.78–0.89)
p value*	0.041	<0.001	<0.001	0.83		<0.001

^*p value comparing FIB-4, APRI and NFS.

^#p value comparing performance of each clinical score among different racial/ethnic groups.

^@p<0.05 vs. Hispanic subjects

^$p<0.05 vs. non-Hispanic White subjects

^{^}p<0.05 vs. non-Hispanic Asian subjects