Table 5.

Performance of clinical scores to predict advanced liver fibrosis (VCTE ≥ 9.7 kPa) and cirrhosis (VCTE ≥ 13.6 kPa) among different racial/ethnic groups in patients at risk for liver disease.

	Hispanic	Non-Hispanic White	Non-Hispanic Black	Non-Hispanic Asian	p value#	Entire cohort
Advanced Fibrosis (F3–4 vs. F0–2)
FIB-4	0.64 (0.57–0.70)	0.61 (0.55–0.66)	0.56 (0.49–0.63)	0.67 (0.55–0.78)	0.33	0.61 (0.58–0.64)
APRI	0.61 (0.54–0.68)	0.62 (0.57–0.67)	0.50 @,$,^ (0.44–0.57)	0.70 (0.58–0.82)	0.010	0.59 (0.56–0.63)
NFS	0.76 (0.70–0.81)	0.73 (0.69–0.78)	0.72 (0.65–0.78)	0.81 (0.71–0.91)	0.43	0.74 (0.71–0.77)
p value*	<0.001	<0.001	<0.001	0.032		<0.001
Cirrhosis (F4 vs. F0–3)
FIB-4	0.76 (0.67–0.86)	0.62 @,^ (0.54–0.71)	0.51 @,^ (0.38–0.64)	0.81 (0.68–0.94)	0.002	0.66 (0.60–0.71)
APRI	0.64 (0.52–0.76)	0.67 ^ (0.59–0.74)	0.51 $,^ (0.40–0.62)	0.82 @ (0.72–0.91)	<0.001	0.64 (0.59–0.70)
NFS	0.85 (0.78–0.92)	0.76 (0.70–0.83)	0.76 (0.65–0.87)	0.89 (0.79–0.99)	0.079	0.80 (0.76–0.84)
p value*	0.002	<0.001	<0.001	0.38		<0.001

^*p value comparing FIB-4, APRI and NFS.

^#p value comparing performance of each clinical score among different racial/ethnic groups.

^@p<0.05 vs. Hispanic subjects

^$p<0.05 vs. non-Hispanic White subjects

^{^}p<0.05 vs. non-Hispanic Asian subjects