Table 2:

Sequential Cox Regression Analysis Using Donor Sex as a Prognostic Risk Factor for All-Cause Mortality and Graft Failure in Liver Transplant Recipients with Primary Sclerosing Cholangitis

Male vs Female Donor
(A) All-Cause Mortality						(B) Graft Failure
Incidence Rates per 1000 Person-Years						Incidence Rates per 1000 Person-Years
			Male	32.38	(28.73 - 36.36)				Male	6.57	(4.97 - 8.52)
			Female	35.18	(30.76 - 40.04)				Female	10.98	(8.56 - 13.88)
Raw Incidence						Raw Incidence
			Male	221					Male	69
			Female	276					Female	56
Sequential Cox Regression Analysis						Sequential Cox Regression Analysis
	Model	p-value		aHR	95% CI		Model	p-value		aHR	95% CI
	1	0.33		0.92	(0.77 - 1.09)		1	0.004 **		0.60	(0.42 - 0.85)
	2	0.31		0.91	(0.76 - 1.09)		2	0.005 **		0.60	(0.42 - 0.86)
	3	0.31		0.91	(0.76 - 1.09)		3	0.004 **		0.60	(0.42 - 0.85)
	† FM	0.47		0.94	(0.78 - 1.12)		† FM	0.01 *		0.63	(0.44 - 0.91)
Mismatch Subanalysis: Female (Sex Mismatch) vs Male Donor in Male Recipients
(A) All-Cause Mortality						(B) Graft Failure
Incidence Rates per 1000 Person-Years						Incidence Rates per 1000 Person-Years
			Male	31.74	(27.55 - 36.37)				Male	6.35	(4.54 - 8.63)
			Female	36.90	(31.15 - 43.38)				Female	12.56	(9.28 - 16.62)
Raw Incidence						Raw Incidence
			Male	141					Male	48
			Female	200					Female	40
Sequential Cox Regression Analysis						Sequential Cox Regression Analysis
	Model	p-value		aHR	95% CI		Model	p-value		aHR	95% CI
	1	0.16		0.86	(0.69 - 1.06)		1	0.002 **		0.51	(0.33 - 0.77)
	2	0.14		0.85	(0.68 - 1.06)		2	0.002 **		0.51	(0.33 - 0.78)
	3	0.13		0.84	(0.68 - 1.05)		3	0.002 **		0.50	(0.33 - 0.77)
	† FM	0.17		0.86	(0.69 - 1.07)		† FM	0.003 **		0.51	(0.33 - 0.79)
Mismatch Subanalysis: Male (Sex Mismatch) vs Female Donor in Female Recipients
(A) All-Cause Mortality						(B) Graft Failure
Incidence Rates per 1000 Person-Years						Incidence Rates per 1000 Person-Years
			Male	34.21	(27.05 - 42.64)				Male	7.20	(4.12 - 11.67)
			Female	32.51	(25.86 - 40.30)				Female	8.53	(5.29 - 13.02)
Raw Incidence						Raw Incidence
			Male	80					Male	21
			Female	76					Female	16
Sequential Cox Regression Analysis						Sequential Cox Regression Analysis
	Model	p-value		aHR	95% CI		Model	p-value		aHR	95% CI
	1	0.94		1.01	(0.74 - 1.39)		1	0.50		0.80	(0.41 - 1.54)
	2	0.97		1.01	(0.73 - 1.39)		2	0.65		0.86	(0.44 - 1.67)
	3	0.99		1.00	(0.72 - 1.38)		3	0.64		0.85	(0.44 - 1.67)
	† FM	0.72		1.06	(0.76 - 1.48)		† FM	0.99		1.00	(0.50 - 2.02)

^*p < 0.05

^**p < 0.01

^***p < 0.001

^†FM indicates Final Model

^*Model 1 includes VOI (variable of interest) and demographics; Model 2 includes Model 1 terms with the addition of comorbidities, and liver disease etiologies; Model 3 includes Model 2 terms with the addition of hepatic variables, MELD score, and liver laboratory markers; Model 4 includes Model 3 terms with the addition of donor demographics