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. Author manuscript; available in PMC: 2025 Jan 1.
Published in final edited form as: Int J Radiat Biol. 2023 Nov 27;100(3):466–485. doi: 10.1080/09553002.2023.2283089

Figure 1.

Figure 1.

Sex difference considerations can impact the outcome of radiation effects and response in many ways, from basic biology (i.e. genetics, pathways), phenotype (natural history of the disease), co-morbidities, lifestyle, radiation exposure, biodose, systematic/systems approach (i.e. individualized response), through medical response. Overall, these areas can be broken down into subcategories: 1) key considerations; 2) factors that impact injury; and 3) response in an ARS setting - how this state-of-the-science would be used today. Ultimately, this information can be used to inform radiation research and medical response to radiation exposure.