Table 2.

Associations and Performance of Novel Measures.

Association of Novel Measures with Qualitative Features of Cerebral Edema
	Sulcal Effacement n = 229	No Sulcal Effacement n = 904	p-value
GWR	1.06 (± 0.17)	1.32 (± 0.12)	< 0.01
HU variance	86 (± 18)	94 (± 18)	< 0.01
Difference between MM means	10.7 (± 2.9)	10.9 (± 2.3)	0.18

	Basal Cistern Effacement n = 121	No Basal Cistern Effacement n = 1012	p-value
GWR	1.04 (± 0.15)	1.29 (± 0.15)	< 0.01
HU variance	86 (± 17)	94 (± 18)	< 0.01
Difference between MM means	10.8 (± 2.8)	10.9 (± 3.0)	0.55

Prediction of Progression to Death by Neurologic Criteria
	AUC (95% CI)	OR (95% CI)	p-value
GWR	0.82 (0.72–0.92)	0.002 (0.00–0.01)	< 0.01
HU variance	0.73 (0.61–0.85)	0.98 (0.96–0.99)	< 0.01
Difference between MM means	0.56 (0.44–0.69)	0.97 (0.90–1.04)	0.38
Culcal effacement	0.80 (0.70–0.90)	26.38 (15.33–47.47)	< 0.01
Cistern effacement	0.76 (0.65–0.86)	19.04 (11.63–31.60)	< 0.01

GWR – Grey-White Matter Ratio; HU – Hounsfield Unit; MM – Mixture Model; AUC – Area under the Receiver Operating Characteristic Curve; CI – Confidence Interval; OR – Odds Ratio