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. 2005 May 10;33(8):2676–2684. doi: 10.1093/nar/gki565

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Schematic representation of the experimental approach. DNA (orange) is stretched between two beads (blue) trapped in optical tweezers. Enzymes (green spheres) in the solution diffuse in search of the recognition sequence (red).