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. Author manuscript; available in PMC: 2024 Mar 8.
Published in final edited form as: Biomacromolecules. 2023 Dec 29;25(2):690–699. doi: 10.1021/acs.biomac.3c00911

Figure 1.

Figure 1.

The six Glucuronoxylomannan (GXM) motifs that build up fungal exo-PS and capsular-PS. GXM is composed of a combination of six repeating units (M1-6), defined by a glucuronic acid (GlcA) residue every 3rd mannose with varying xylose substitutions. These 6 motifs of GXM in various combinations correlate to different serotype activities19. C. neoformans H99 serotype A has a dominant M2 motif in exo- and capsular-PS20. Polysaccharide molecules can be heteropolymers composed of more than one triad17. Image created with DrawGlycan-SNFG21.