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Classification of gastroenteropancreatic neuronendocrine neoplasms (WHO, 2019) 4.
| Terminology | Differentiation | Grade | Ki-67 index | Mitotic rate (mitoses/10HPF) |
|---|---|---|---|---|
| G1 NET | Well differentiated | Low | <3% | <2 |
| G2 NET | Intermediate | 3-20% | 2-20 | |
| G3 NET | High | >20% | >20 | |
| NEC | Poorly differentiated | High | >20% | >20 |
In cases of disparity between Ki-67 index and mitotic rate, the result that indicates a higher grade tumor should be selected.
