Table 2.

Significant Tat and/or morphine-dependent correlations between monoamine concentrations and alterations in behavior ^a

Morphine-treated mice b
Variables	Correlation	df	z-value	p-value	FDR p-value
DA, Distance	−0.347	34	−2.082	0.0374*	0.0941
DA, Speed	−0.343	34	−2.053	0.0400*	0.0941
DA, Time Active	−0.333	34	−1.990	0.0466*	0.0941
DA, Rearing Events	−0.344	34	−2.060	0.0394*	0.0941
NE, Distance	0.369	34	2.226	0.0260*	0.0556
NE, Speed	0.366	34	2.204	0.0275*	0.0556
NE, Time Active	0.379	34	2.293	0.0219*	0.0556
NE, Rearing Events	0.470	34	2.931	0.0034*	0.0275*
DOPAC, Distance	−0.387	34	−2.348	0.0189*	0.0574
DOPAC, Speed	−0.381	34	−2.303	0.0213*	0.0574
DOPAC, Time Active	−0.406	34	−2.473	0.0134*	0.0574
HVA/DA, Distance	0.343	34	2.051	0.0403*	0.1681
HVA/DA, Speed	0.341	34	2.038	0.0416*	0.1681
5-HIAA/5-HT, Time Active	−0.341	34	−2.041	0.0413*	0.1669
5-HIAA/5-HT, Rearing Events	−0.350	34	−2.099	0.0358*	0.1669

^aOnly significant correlations are presented in Table 2 for brevity. All tested correlations (significant and non-significant) are presented in Supplementary Table 1.

^bThe correlation coefficients, degrees of freedom (df), z-values, and uncorrected and false discover rate (FDR) corrected p-values from the z-test correlation results of dopamine (DA), norepinephrine (NE), DOPAC, 5-HIAA, HVA, DOPAC/DA, HVA/DA, 5-HIAA/5-HT (serotonin), and 3-MT/DA with 12 behavioral outcomes. Hypothesized correlation coefficient = 0

^*p < 0.05.

Distance, speed, time active, rearing events, and center latency were measured in the open field assay. Nose-pokes and time nose-poking were assessed in the exploratory hole board test. Latency to interact was assessed by reciprocal social interaction. Results from n = 72 mice (9 per group).