Table 2.
PRL and non-rim WM lesion spatial distribution and comparisons
| Lesion type/total WM lesion | Lesion type in a band/Lesion type in all the bands | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MS | RRMS | SPMS | RR vs SPMS p-value | MS | RRMS | SPMS | RR vs SPMS p-value | Band/tot ratio | Band/tot ratio PRL vs non-rim, p-value | ||
| PRL | Count, mean (SD) | 3.9 (6.5) | 2.6 (2.9) | 7.7 (11.6) | 0.066 | 0.087 (0.079) | 0.092 (0.081) | 0.072 (0.073) | 0.280 | - | - |
| Tot volume (mm3), mean (SD) | 1092 (2474) | 772 (1593) | 2074 (4089) | 0.157 | 0.220 (0.216) | 0.237 (0.223) | 0.165 (0.187) | 0.221 | - | - | |
| Periventricular volume (mm3), mean (SD) | 803 (1969) | 535 (1002) | 1624 (3526) | 0.180 | 0.158 (0.192) | 0.170 (0.200) | 0.121 (0.167) | 0.541 | 0.67 (0.34) | 0.021 | |
| Paraventricular volume (mm3), mean (SD) | 207 (554) | 164 (543) | 336 (585) | 0.219 | 0.038 (0.055) | 0.040 (0.057) | 0.033 (0.048) | 0.912 | 0.22 (0.28) | 0.213 | |
| 21–30 mm from ventricle volume (mm3), mean (SD) | 66 (201) | 59 (195) | 91 (226) | 0.166 | 0.018 (0.048) | 0.021 (0.055) | 0.010) (0.018) | 0.422 | 0.09 (0.23) | <0.001 | |
| 31–40 mm from ventricle volume (mm3), mean (SD) | 14 (69) | 12 (64) | 21 (84) | 0.969 | 0.006 (0.030) | 0.007 (0.035) | 0.001 (0.005) | 0.969 | 0.02 (0.10) | <0.001 | |
|
Non-rim WM
lesion |
Count, mean (SD) | 53.7 (55.4) | 39.5 (31.9) | 97.33 (84.8) | 0.003 | 0.912 (0.079) | 0.908 (0.081) | 0.928 (0.073) | 0.280 | - | - |
| Tot volume (mm3), mean (SD) | 3362 (4208) | 2403 (3308) | 6302 (5332) | <0.001 | 0.780 (0.216) | 0.763 (0.223) | 0.834 (0.187) | 0.221 | - | - | |
| Periventicular volume (mm3), mean (SD) | 2196 (2980) | 1502 (2420) | 4324 (3578) | <0.001 | 0.437 (0.212) | 0.337 (0.202) | 0.561 (0.197) | 0.016 | 0.56 (0.21) | - | |
| Paraventricular volume (mm3), mean (SD) | 691 (930) | 511 (701) | 1246 (1301) | 0.013 | 0.187 (0.121) | 0.192 (0.126) | 0.170 (0.106) | 0.558 | 0.24 (0.13) | - | |
| 21–30 mm from ventricle volume (mm3), mean (SD) | 378 (423) | 292 (315) | 643 (589) | 0.034 | 0.121 (0.094) | 0.130 (0.102) | 0.092 (0.057) | 0.375 | 0.15 (0.11) | - | |
| 31–40 mm from ventricle volume (mm3), mean (SD) | 95 (132) | 98 (144) | 88 (84) | 0.663 | 0.036 (0.045) | 0.044 (0.049) | 0.012 (0.010) | 0.052 | 0.05 (0.06) | - | |
Significance testing:
RR vs SPMS: Mann-Whitney test
Band/tot ratio PRL vs non-rim WM lesions: Wilcoxon signed rank test between correspondent bands Bold indicates a statistically significant difference with a p-value<0.05
Abbreviations: MS: multiple sclerosis; PRL: paramagnetic rim lesions; RRMS: relapsing-remitting MS; SD: standard deviation; SPMS: secondary progressive MS; WM: white matter