Table 3.

Gene set enrichment analysis utilizing Reactome Gene Set Database reveals upregulation of “Extracellular Matrix Organization” and “Extracellular Matrix Proteoglycans” in superficial injured compared to contralateral cortical tissue 7 days post-TBI. Red indicates upregulated gene sets and blue indicates downregulated gene sets. ES = Enrichment Score, NES = Normalized Enrichment Score, NOM = nominal, FDR = False Discovery Rate, FWER = Family-Wise Error Rate

Gene Set Name	Gene Set Size	ES	NES	NOM p-val	FDR q-val	FWER p-val
EXTRACELLULAR MATRIX ORGANIZATION	283	0.51	2.35	<0.001	<0.001	<0.001
COMPLEMENT CASCADE	45	0.67	2.34	<0.001	<0.001	<0.001
ELASTIC FIBRE FORMATION	43	0.68	2.34	<0.001	<0.001	<0.001
INTEGRIN CELL SURFACE INTERACTIONS	83	0.60	2.33	<0.001	<0.001	<0.001
DISEASES OF IMMUNE SYSTEM	30	0.73	2.30	<0.001	<0.001	<0.001
EXTRACELLULAR MATRIX PROTEOGLYCANS	76	0.60	2.29	<0.001	<0.001	<0.001
NEUTROPHIL DEGRANULATION	432	0.48	2.28	<0.001	<0.001	<0.001
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	81	0.57	2.26	<0.001	<0.001	<0.001
SYNDECAN INTERACTIONS	27	0.71	2.26	<0.001	<0.001	<0.001
INTERLEUKIN 10 SIGNALING	41	0.65	2.23	<0.001	0.002	0.002
POTASSIUM CHANNELS	102	−0.60	−2.16	<0.001	<0.001	<0.001
VOLTAGE GATED POTASSIUM CHANNELS	43	−0.69	−2.16	<0.001	<0.001	0.001
DAG AND IP3 SIGNALING	40	−0.65	−2.00	<0.001	0.0072	0.022
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	61	−0.61	−2.00	<0.001	0.0061	0.025
NEURONAL SYSTEM	394	−0.48	−1.99	<0.001	0.0057	0.03
NEUREXINS AND NEUROLIGINS	54	−0.61	−1.97	<0.001	0.0069	0.044