Table 4.

Significantly altered glycosaminoglycan biosynthesis enzymes in superficial injured compared to contralateral cortical tissue 7 days post-TBI. ** FDR p value < 0.01.

Glycosaminoglycan Pathway	Gene Name	Gene Symbol	Function	Fold Change	FDR p-value
HS Biosynthesis	exostoses (multiple)-like 3	Extl3	Backbone elongation	−33%	0.0037
	heparan sulfate 2-O-sulfotransferase 1	Hs2st1	2-Sulfation	−29%	0.0104
	exostoses (multiple)-like 1	Extl1	Backbone elongation	−28%	0.0208
	exostoses (multiple)-like 2	Extl2	Backbone elongation	−25%	0.0223
	N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4	Ndst4	N-sulfation	490%	0.0257
	exostoses (multiple) 1	Ext1	Backbone elongation	−43%	0.0262
CS + HS Biosynthesis	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	B3gat3	Backbone elongation	−26%	0.0241
HA Biosynthesis	hyaluronan synthase 2	Has2	Elongation	29%	0.0264