Table 1.

Clinical parameters of TNFR2 agonism in EAE females indicate reduced cumulative motor disease and delayed onset. The day of motor deficit onset was defined as the first day when a mouse scored at least 2 for two consecutive days. The cumulative disease index (CDI), which was calculated as the sum of clinical scores between days 10 and 30, represents a measure for disease severity over time.

	Females			Males
	Vehicle	p53-sc-mTNFR2	Sign.	Vehicle	p53-sc-mTNFR2	Sign.
CDI	40.25	26.25	* **p < 0.001	20.88	21.88	n.s.
	n = 17	n = 15		n = 10	n = 12
Day of Onset	15.00	18.00	* *p < 0.01	19.50	21.00	n.s.
	n = 17	n = 15		n = 10	n = 12