Table 2. M1 and M10 RAD51C variants.

RAD51C variants identified on ClinVar and gnomAD. The variants in black text were analyzed in this study whereas the variants in grey text were excluded from analysis since they were recently added to ClinVar. The variant, nucleotide change, population frequency from gnomAD, the number of affected individuals, and variant source are shown. Table last updated 8/25/23.

Variant	Nucleotide Change	Population Frequency	Affected Individuals	Cancer Type	Source
M1I	3G>C 3G>A 3G>T	- 3.19 × 10−5 -	1 7 7	Not listed Breast Breast, Ovarian	ClinVar ClinVar, gnomAD, [22] ClinVar, [23]
M1L	1A>T	-	3		ClinVar
M1V	1A>G	-	4		ClinVar
M1T	2T>C	-	1		ClinVar
M10I	30G>T 30G>A	3.98 × 10−6 3.98 × 10−6	3 1		ClinVar, gnomAD ClinVar, gnomAD
M10K	29T>A	-	1		ClinVar
M10L	28A>T	3.19 × 10−5	5	Breast	ClinVar, gnomAD, [24]
M10R	29T>G	7.95 × 10−5	11	Breast, Ovarian	ClinVar, gnomAD, [25], [26], [27], [28]
M10T	29T>C	-	1		ClinVar
M10V	28A>G	-	2		ClinVar