TABLE 4.
Primary analysis: associations of CAKS, KDPI, and Remuzzi score with eGFR at 1 y
| Characteristic | CAKS-only model | CAKS + KDPI | CAKS + KDPI + Remuzzi | |||
|---|---|---|---|---|---|---|
| Beta (95% CI) | P | Beta (95% CI) | P | Beta (95% CI) | P | |
| Total scores | ||||||
| CAKS total score | −8.7 (−13.0 to −4.4) | <0.001 | −4.8 (−9.6 to 0.1) | 0.056 | −4.6 (−9.5 to 0.3) | 0.065 |
| KDPI | −0.3 (−0.5 to −0.1) | 0.002 | −0.3 (−0.5 to −0.1) | 0.005 | ||
| Remuzzi total score | −1.6 (−5.2 to 2.0) | 0.386 | ||||
| Individual components | ||||||
| CAKS: vessel | −12.1 (−19.4 to −4.8) | 0.002 | −7.6 (−15.3 to 0.2) | 0.057 | −7.4 (−15.2 to 0.5) | 0.068 |
| CAKS: anatomy | −4.7 (−16.5 to 7.1) | 0.437 | −2.9 (−14.4 to 8.7) | 0.627 | −3.4 (−15.2 to 8.4) | 0.575 |
| CAKS: sticky fat | −6.5 (−14.3 to 1.3) | 0.106 | −2.6 (−10.6 to 5.4) | 0.526 | −2.8 (−11.1 to 5.4) | 0.499 |
| KDPI | −0.3 (−0.5 to −0.1) | 0.003 | −0.3 (−0.5 to −0.1) | 0.008 | ||
| Remuzzi: interstitial fibrosis | 2.4 (−11.1 to 15.8) | 0.731 | ||||
| Remuzzi: tubular | −10.0 (−27.0 to 7.0) | 0.250 | ||||
| Remuzzi: vascular | −0.3 (−9.5 to 9.0) | 0.954 | ||||
| Remuzzi: glomerular | −1.0 (−7.0 to 5.0) | 0.737 | ||||
Association between CAKS total score and eGFR at 1 y after transplantation estimated in 3 models: a model with only the CAKS total score variable (left), a model adjusting for KDPI (middle), and a model adjusting for KDPI and Remuzzi total score (right). Beta coefficients represent the difference in mean eGFR at 1 y associated with a 1-point increase in the predictor variables (eg, increase from KDPI 30 to KDPI 31, increase in CAKS from 0 to 1, etc).
CAKS, Canadian Anatomic Kidney Score; CI, confidence interval; eGFR, estimated glomerular filtration rate; KDPI, Kidney Donor Profile Index.