Table 2. MR estimates of the causal association between SB/PA/SD and the risk of obesity.
| Obesity | ||||||
|---|---|---|---|---|---|---|
| Exposure | Methods | OR (95% CI) | p | F-statistic | ||
| LST | MR Egger | 1.79 (0.99, 3.21) | 0.06 |
113.19 |
||
| LST | Weighted median | 1.72 (1.44, 2.05) | 1.58×10−9 | |||
| LST | IVW | 1.62 (1.43, 1.84) | 6.49×10−14 | |||
| LST | Simple mode | 1.91 (1.33, 2.74) | 9.47×10−04 | |||
| LST | Weighted mode | 1.83 (1.29, 2.60) | 1.50×10−03 | |||
| Television watching | MR Egger | 2.04 (0.92, 4.55) | 0.09 |
47.57 |
||
| Television watching | Weighted median | 1.65 (1.24, 2.20) | 5.83×10−4 | |||
| Television watching | IVW | 1.55 (1.27, 1.90) | 1.67×10−5 | |||
| Television watching | Simple mode | 2.38 (1.19, 4.74) | 0.02 | |||
| Television watching | Weighted mode | 2.24 (1.21, 4.14) | 0.01 | |||
| Computer use | MR Egger | 27.49 (1.34, 563.20) | 0.05 |
28.11 |
||
| Computer use | Weighted median | 1.60 (1.00, 2.56) | 0.05 | |||
| Computer use | IVW | 1.52 (1.08, 2.13) | 1.61×10−2 | |||
| Computer use | Simple mode | 1.61 (0.67, 3.84) | 0.30 | |||
| Computer use | Weighted mode | 1.86 (0.77, 4.46) | 0.18 | |||
| Driving | MR Egger | 2.61 (0.01, 627.55) | 0.74 |
43.88 |
||
| Driving | Weighted median | 1.61 (0.79, 3.27) | 0.19 | |||
| Driving | IVW | 2.79 (1.25, 6.21) | 1.23×10−2 | |||
| Driving | Simple mode | 1.39 (0.55, 3.50) | 0.50 | |||
| Driving | Weighted mode | 1.39 (0.55, 3.54) | 0.50 | |||
| SB at work | MR Egger | 2.74 (0.18, 41.59) | 0.54 |
124.45 |
||
| SB at work | Weighted median | 1.17 (0.77, 1.76) | 0.46 | |||
| SB at work | IVW | 1.23 (0.86, 1.75) | 0.26 | |||
| SB at work | Simple mode | 1.01 (0.54, 1.88) | 0.97 | |||
| SB at work | Weighted mode | 1.01 (0.56, 1.84) | 0.97 | |||
| Sedentary commuting | MR Egger | 0.80 (0.46, 1.41) | 0.50 |
53.31 |
||
| Sedentary commuting | Weighted median | 1.09 (0.78, 1.52) | 0.63 | |||
| Sedentary commuting | IVW | 1.19 (0.92, 1.55) | 0.18 | |||
| Sedentary commuting | Simple mode | 1.07 (0.67, 1.73) | 0.78 | |||
| Sedentary commuting | Weighted mode | 1.06 (0.66, 1.69) | 0.83 | |||
| MVPA | MR Egger | 0.08 (0.00, 1.68) | 0.65 | |||
| MVPA | Weighted median | 0.87 (0.44, 1.73) | 0.15 |
30.49 |
||
| MVPA | IVW | 0.88 (0.52, 1.48) | 0.70 | |||
| MVPA | Simple mode | 1.50 (0.44, 5.10) | 0.63 | |||
| MVPA | Weighted mode | 0.64 (0.18, 2.19) | 0.53 | |||
| Acc425 | MR Egger | 1.43 (0.56, 3.70) | 0.48 |
17.78 |
||
| Acc425 | Weighted median | 0.82 (0.53, 1.27) | 0.38 | |||
| Acc425 | IVW | 0.73 (0.52, 1.01) | 0.05 | |||
| Acc425 | Simple mode | 0.79 (0.39, 1.60) | 0.53 | |||
| Acc425 | Weighted mode | 0.80 (0.41, 1.58) | 0.54 | |||
| AccAve | MR Egger | 0.96 (0.37, 2.49) | 0.94 |
1979.98 |
||
| AccAve | Weighted median | 0.94 (0.88, 1.01) | 0.12 | |||
| AccAve | IVW | 0.96 (0.83, 1.10) | 0.53 | |||
| AccAve | Simple mode | 0.91 (0.81, 1.02) | 0.20 | |||
| AccAve | Weighted mode | 0.92 (0.83, 1.01) | 0.19 | |||
| SD | MR Egger | 0.83 (0.43, 1.57) | 0.58 |
40.65 |
||
| SD | Weighted median | 0.96 (0.71, 1.29) | 0.78 | |||
| SD | IVW | 0.94 (0.76, 1.17) | 0.60 | |||
| SD | Simple mode | 0.90 (0.53, 1.55) | 0.72 | |||
| SD | Weighted mode | 0.82 (0.49, 1.38) | 0.48 | |||
Abbreviations: SB, sedentary behavior; PA, physical activity; SD, sleep duration; CI, confidence interval; MR, Mendelian randomization; OR, odds ratio; IVW, Inverse variance weighted; LST, Leisure screen time; SB at work, Sedentary Behavior at work; MVPA, moderate to vigorous physical activity; Acc425, accelerometer-based physical activity with accelerations>425 milli-gravities; AccAve, accelerometer-based physical activity with average acceleration; SD, Sleep duration.