Table 2.
Main pharmacokinetic parameters after intragastric (5 mg/kg) and intravenous (1 mg/kg) administration of ziyuglycoside I and ziyuglycoside II in rats.
| Compound | Group | AUC(0-t) | AUC(0-∞) | t 1/2z | CLz/F | V z/F | C max |
|---|---|---|---|---|---|---|---|
| ng/mL ∗ h | ng/mL ∗ h | h | L/h/kg | L/kg | ng/mL | ||
| Ziyuglycoside I | ig | 95.4 ± 7.2 | 109.0 ± 11.8 | 5.1 ± 2.5 | 46.3 ± 5.2 | 329.2 ± 143.6 | 36.6 ± 5.8 |
| iv | 834.7 ± 249.2 | 838.3 ± 250.3 | 1.8 ± 0.7 | 1.3 ± 0.3 | 3.5 ± 2.0 | 1268.0 ± 344.8 | |
|
| |||||||
| Ziyuglycoside II | ig | 438.9 ± 42.4 | 458.3 ± 46.3 | 4.9 ± 1.5 | 11.0 ± 1.0 | 77.3 ± 22.5 | 102.2 ± 14.5 |
| iv | 1933.2 ± 209.1 | 1979.2 ± 185.7 | 6.2 ± 3.1 | 0.5 | 4.6 ± 2.4 | 1374.3 ± 224.5 | |