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. 2024 Mar 8;12:28. doi: 10.1186/s40635-024-00609-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Effects of age on mortality, MSS, and body temperature in a 72 h FIP model of sepsis. Kaplan–Meier survival curves (A and B), MSS (C), and body temperature (D) over time in aged and young FIP mice. Mice that survived till experimental endpoint are designated as survivors. Mice that were humanely euthanized according to their MSS are designated as non-survivors. Aged FIP (n = 9), young FIP (n = 12), aged sham (n = 3), and young sham (n = 3). Data are presented as mean ± SD. Survival curves were analyzed using a Log-rank (Mantel-Cox) test. Bacterial loads were analyzed using a one-way ANOVA. P-values < 0.05 were considered significant. Bacterial loads for PCF (E) and blood (F) in aged and young FIP survivors and non-survivors. (Note: For 1 aged FIP non-survivor, unable to collect blood and for 1 young FIP survivor, blood and PCF colonies were too confluent to count).