Fig. 6.
Histology scores in the lung, liver, and kidney in aged and young mice in a 72 h FIP model of sepsis. The lung, liver, and kidney of aged and young mice were harvested at humane or experimental endpoint, stained with H&E, and scored. Representative images of the lung, liver, and kidney for aged and young FIP mice are provided (A). Organ injury scores for the lung (B), liver (C), and kidney sections (D) were based on inflammation, thrombosis, and organ morphology. Mice that survived till experimental endpoint are designated as survivors. Mice that were humanely euthanized according to their MSS are designated as non-survivors. Aged FIP survivors (n = 1), aged FIP non-survivors (n = 6), aged sham mice (n = 3), young FIP survivors (n = 7), young FIP non-survivors (n = 5), and young sham mice (n = 3). Data are presented as mean ± SD and the data was analyzed using a one way-ANOVA. P-values < 0.05 were considered significant. Scale bars represent 50 m