Table 3.
Summary of meta-analysis of Klotho with each sensitivity analysis.
| Analysis and subgroup analysis | Effect measure | Pooled effect (95% CI) | I2 (%) | n | P value | Analysis model |
|---|---|---|---|---|---|---|
| Correlation between Klotho level and calcification score | Pooled r | − 0.388 (− 0.578 to − 0.159) | 92 | 8 | 0.001 | RE |
| CKD only | − 0.485 (− 0.658 to − 0.273) | 90 | 6 | < 0.0001 | RE | |
| Severe CKD only | − 0.523 (− 0.73 to 0.226) | 91 | 4 | 0.001 | RE | |
| High quality studies only | − 0.159 (− 0.264 to − 0.05) | 47 | 3 | 0.005 | RE | |
| Correlation between Klotho level and CIMT | Pooled r | − 0.38 (− 0.53 to − 0.207) | 80 | 5 | < 0.00001 | RE |
| CKD only | − 0.26 (− 0.44 to − 0.07) | 55 | 2 | 0.008 | RE | |
| High quality studies only | − 0.38 (− 0.55 to − 0.21) | 42 | 3 | < 0.0001 | RE | |
| Klotho levels difference between groups with and without arterial calcification | Pooled SMD | − 0.04 (− 0.33 to 0.24) | 0 | 2 | 0.76 | RE |
| Klotho levels difference between groups with and without arterial thickness | Pooled SMD | − 1.63 (− 3.11 to − 0.15) | 97 | 3 | 0.03 | RE |
| Without Castelblanco | − 2.27 (− 2.82 to − 1.72) | 49 | 2 | < 0.00001 | RE |
CKD chronic kidney disease, RE random effect, SMD standardized mean difference.