Table 3.
Results of Cox regression analysis for predicting insulin prescription and T2DM complications.
| Prediction | PRS | Hazard ratio | 95% CI | P-value |
|---|---|---|---|---|
| Insulin prescription | Categorized PRS | |||
| Remaining | 1.00 (reference) | |||
| Top decile | 1.692 | 1.075–2.662 | 0.0231 | |
| Standardized PRS | 1.663 | 1.331–2.077 | 7.61E−06 | |
| T2DM complications | Categorized PRS | |||
| Bottom decile | 0.7841 | 0.4290–1.433 | 0.429 | |
| Middle (10–90%) | 1.00 (reference) | |||
| Top decile | 0.8992 | 0.6900–1.172 | 0.432 | |
| Standardized PRS | 0.9878 | 0.8910–1.095 | 0.816 |
Cox regression model was used with sex and time from T2DM diagnosis to insulin prescription or T2DM complications in a year. For the insulin prescription prediction, participants were classified into two groups according to a percentile of PRS: top decile and remaining ( 90%). T2DM complications include myocardial infarction, coronary artery disease, congestive heart failure, cerebrovascular disease, peripheral artery disease, and kidney disease. T2DM: type 2 diabetes mellitus.