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. 2024 Mar 8;15:2137. doi: 10.1038/s41467-024-46458-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Heatmap of differentially expressed TE. b Volcano plot of TE in heart tissues. A statistical test based on the H0 and H1 model fitting. c Venn diagram showing the overlap of genes of differentially expressed RPF and TE, and unchanged RNA. d KEGG analysis of genes with translational regulation by DAVID and HIPLOT. Fisher exact test. e The KEGG analysis of genes with down-regulated translation. Fisher exact test. f The fold changes of RNA (FPKM, F test), RPF (CPM, likelihood ratio test) and TE (FPKM, a statistical test based on the H0 and H1 model fitting) of Uqcr11, Uqcrb and Atp5j2 in RNA-seq and Ribo-seq data (n = 3 independent mice). g, h The mRNA and protein expression level of Uqcrb, Uqcr11 and Atp5j2 in AR heart tissues (g, n = 3 independent mice; h n = 5 independent mice). Two-tailed Student’s t test with g or without Welch’s correction h. i The translational regulation of Uqcrb, Uqcr11 and Atp5j2 in AR heart tissues analyzed by polysome profiling (n = 3 independent mice). *p < 0.05, **p < 0.01, ***p < 0.001 vs. sham group, ns, not significant. Data are presented as mean ± SEM. Source data are provided as a Source Data file. Exact p values are provided in the Source Data file.