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. 2024 Mar 8;15:2137. doi: 10.1038/s41467-024-46458-7

Fig. 7. Nat10 promotes cardiomyocyte proliferation and improves cardiac functions in adult mice with MI.

Fig. 7

a, b Cardiac sections from hearts stained with pH3 and Ki67 at 7 days after MI. Arrows, pH3/Ki67-positive signal (n = 6 mice). ***p < 0.001 as indicated. White arrows point the positive cardiomyocytes. c Echocardiography was used to observe cardiac function of adult mice at 28 days after MI (n = 6 mice). ***p < 0.001 as indicated. d The fibrosis of adult mice after MI for one month was studied using Masson staining (n = 4 mice). **p < 0.01 vs. WT. e Polysome profiling analysis of Uqcrb and Uqcr11 (n = 3 mice). f Representative western blots and averaged data showing downregulated Uqcr11 and Uqcrb in the hearts from WT and cardiomyocyte-specific Nat10 overexpression mouse hearts (n = 4 mice). *p < 0.05, **p < 0.01 vs. WT. Two-tailed Student’s t test with (a, b, f, Uqcrb) or without a–d Welch’s correction. Data are presented as mean ± SEM. Scale bar: 50 μm a, b, 500 μm d. Source data are provided as a Source Data file. Exact p values are provided in the Source Data file.