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. 2024 Mar 8;15:2137. doi: 10.1038/s41467-024-46458-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a The expression of Nat10 in male pig heart tissues after birth (n = 3 pigs). **p < 0.01 vs. P1. b The expression of Nat10 in cardiomyocytes isolated from male pig heart tissues (n = 3 pigs). *p < 0.05 vs. P1. c The translational regulation of Uqcrb and Uqcr11 in P1 and P7 male pig heart tissues analyzed by polysome profiling (n = 3 pigs). d The expression of Nat10 in cardiomyocytes isolated from female human failing and non-failing hearts (n = 3 hearts). ***p < 0.001 vs. non-HF. e Immunofluorescence staining showing the expression of EdU in cardiomyocytes derived from human ESCs with overexpression or knockdown of Nat10 (n = 3 independent experiments). White arrows point the positive cardiomyocytes. f The effects of Nat10 knockdown on AC16 cardiomyocyte cell cycle determined by immunofluorescence staining (n = 3 independent experiments). **p < 0.01, ***p < 0.001 vs. NC siRNA. g Polysome profiling analysis of Uqcrb and Uqcr11 in Nat10-overexpressed human cardiomyocytes (n = 3 independent experiments). Two-tailed Student’s t test with b, f or without Welch’s correction a, d. Data are presented as mean ± SEM. Scale bar: 50 μm e. Source data are provided as a Source Data file. Exact p values are provided in the Source Data file.