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. 2024 Mar 8;9:54. doi: 10.1038/s41541-024-00836-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Serum soluble mediators (chemokines = ; cytokines = and growth factors = ) were quantified by high-throughput microbeads array and data expressed as median baseline fold change indices, calculated as described in Materials and Methods. The results are reported as scattering distribution of individual data at distinct timepoints (D7 = ; D10-15 = ; D30-45 = ). Dotted lines represent the cutoff to categorize data as decreased (<1), unaltered (=1) or increased (>1). Only significant differences identified by Kruskal–Wallis test or ANOVA variance analysis were shown. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Numbers below bars indicate the proportion of individuals with fold changes >1. Chi-square test was used for comparative analysis of proportion of vaccinees with baseline fold change >1 and underscored by the letters “a” and “b” for comparisons with D7 and D10-15, respectively.

Inline graphic — Serum soluble mediators (chemokines = ; cytokines = and growth factors = ) were quantified by high-throughput microbeads array and data expressed as median baseline fold change indices, calculated as described in Materials and Methods. The results are reported as scattering distribution of individual data at distinct timepoints (D7 = ; D10-15 = ; D30-45 = ). Dotted lines represent the cutoff to categorize data as decreased (<1), unaltered (=1) or increased (>1). Only significant differences identified by Kruskal–Wallis test or ANOVA variance analysis were shown. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Numbers below bars indicate the proportion of individuals with fold changes >1. Chi-square test was used for comparative analysis of proportion of vaccinees with baseline fold change >1 and underscored by the letters “a” and “b” for comparisons with D7 and D10-15, respectively.