Fig. 4. Primary vaccination with Fractional and Standard dose of 17DD-YF vaccine induced a distinct timeline kinetics of serum biomarkers.

Serum soluble mediators were quantified by high-throughput microbeads array and data expressed as median baseline fold change indices, calculated as described in Materials and Methods. The results are reported as a line chart expressing the median values observed for FD (chemokines = ; cytokines =  and growth factors = ) and SD (chemokines =  ; cytokines =  and growth factors = ) at each time point. Lines with darker colors represent the Standard dose timeline, and lines with lighter colors denote the Fractional dose timeline. Dotted lines represent the cutoff to categorize data as decreased (<1), unaltered (=1) or increased (>1). Only significant differences identified by Mann–Whitney test were shown. *p < 0.05; **p < 0.01; ***p < 0.001.