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. 2024 Mar 9;14:5778. doi: 10.1038/s41598-024-56543-y

Table 4.

Potential risk factor for relapse after IN discontinuation.

Relapse within a year (N = 50) More than 1-year remission (N = 22) Univariate analyses (P value) Multivariate analyses (P value)
Age at diagnosis, years; mean (± SD) 29.2 (± 15.1) 25.9 (± 11.2) 0.259
Disease duration, years; mean (± SD) 8.4 (± 7.8) 8.1 (± 6.8) 0.855
Extent of disease (extensive/left-side proctitis) 27/23 (54%/46%) 15/7 (68.1%/31.8%) 0.261 0.318
Duratioin of IN use, week; mean (± SD) 29 (± 41) 21.4 (± 11.2) 0.497 0.983
Amount of IN used, g; mean (± SD) 223 (± 230) 188 (± 105) 0.836
Previous corticosteroid use 37 (74%) 13 (59.0%) 0.373 0.108
Biologic naive 30 (60%) 13 (59.0%) 0.771 0.236
Albumin (mg/dL) at IN discontinuation 4.49 (± 0.42)/13.4% 4.54 (± 0.31)/10.5% 0.366
Hemoglobin (g/dL) at IN discontinuation
 Male 13.4 (± 1.55) 14.4 (± 1.63) 0.107
 Female 12.4 (± 1.62) 12.8 (± 0.74) 0.152

Data are presented as mean (± SD) and number (percentage).

IN indigo naturalis, SD standard deviation.