Table 1.
Serum bactericidal activity against OAg-positive S. sonnei strain for sera depleted and non-depleted of LPS specific antibodies, in participants vaccinated with 1790GAHB (per protocol immunogenicity set)
| Depleted sera | Non-depleted sera33 | |||
|---|---|---|---|---|
| N | GMT (95% CI) | N | GMT (95% CI) | |
| Day 1 | 34 | 16.50 (16.50–16.50) | 32 | 81.95 (57.27–117.26) |
| Day 29 | 34 | 16.50 (16.50–16.50) | 32 | 204.65 (113.56–368.80) |
| Day 57 | 34 | 16.50 (16.50–16.50) | 32 | 171.11 (99.57–294.04) |
The lower limit of quantification (LLOQ) for the assay used to assess S. sonnei bactericidal titers after LPS-specific antibodies depletion was an inhibition concentration 50 (IC50) of 33. Titers below the LLOQ were set to half that limit for the purpose of the analysis.
OAg O antigen, LPS lipopolysaccharide, N number of participants, GMT geometric mean titer, CI confidence interval.