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. 2024 Mar 1;71(3):378–389. doi: 10.1007/s12630-024-02692-7

Table 3.

Associations between AChE and BChE activities with inflammatory markers and laboratory data of patients with viral sepsis

Variable AChE BChE
Time ρa 95% CI P value n ρa 95% CI P value n
Hb (mmol·L−1) T1 0.51 0.35 0.63  < 0.001 108 0.13 −0.06 0.31 0.19 108
T2 0.38 0.19 0.54  < 0.001 97 0.20 0.00 0.38 0.049 97
Albumin (g·L−1) T1 0.23 0.04 0.40 0.02 107 0.36 0.19 0.52  < 0.001 107
T2 0.29 0.09 0.47 0.004 93 0.35 0.16 0.52  < 0.001 93
ChE (µmol·L−1) T1 0.19 0.00 0.37 0.048 107 0.55 0.40 0.67  < 0.001 107
T2 0.23 0.03 0.41 0.03 93 0.51 0.34 0.65  < 0.001 93
PCT (ng·L−1) T1 −0.17 −0.35 0.02 0.08 108 −0.29 −0.45 −0.11 0.002 108
T2 −0.17 −0.36 0.03 0.09 97 −0.27 −0.44 −0.07 0.008 97
CRP (mg·L−1) T1 −0.19 −0.36 0.00 0.05 108 −0.25 −0.42 −0.06 0.01 108
T2 −0.24 −0.42 −0.05 0.02 97 −0.34 −0.51 −0.15  < 0.001 97
Ferritin (µg·mL−1) T1 0.16 −0.03 0.35 0.10 104 0.05 −0.15 0.24 0.62 104
T2 0.05 −0.15 0.25 0.63 93 −0.01 −0.21 0.20 0.95 93
IL–6 (pg·mL−1) T1 −0.03 −0.22 0.16 0.75 105 −0.06 −0.25 0.14 0.57 105
T2 −0.21 −0.40 −0.01 0.04 94 −0.26 −0.44 −0.06 0.01 94

aSpearman’s rank correlation coefficient with 95% CI and P value (P < 0.05 are printed in bold)

AChE = acetylcholinesterase; BChE = butyrylcholinesterase; CI = confidence interval; CRP = C-reactive protein; ChE = cholinesterase; Hb = hemoglobin; IL-6 = interleukin-6; PCT = procalcitonin; SOFA = sequential organ failure assessment score; T1 = 3 ± 1 days after onset of sepsis; T2 = 7 ± 1 days after onset of sepsis