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. 2024 Mar 6;13(4):187–199. doi: 10.1089/wound.2023.0097

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© Paulina Słonimska et al., 2024; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The effect of chemotherapy on skin cells by blocking the synthesis of growth factors. Chemotherapy-mediated decrease in the production of growth factors is one of the causes of complications in wound healing. In a properly progressing wound healing process, cells in and around the wound synthesize PDGF, TGF-β, and EGF. These factors, especially PDGF, are a strong attractant of neutrophils, monocytes, and fibroblasts. Chemotherapeutic agents block the synthesis of growth factors, leading to a delay in cell migration, proliferation disruption, and angiogenesis reduction. (The drawing was created with BioRender.com)